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KMID : 1007520000090050304
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Food Science and Biotechnology
2000 Volume.9 No. 5 p.304 ~ p.307
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Structure - Activity Relationship of Dietary Flabonoids for Inhibitory Activity of Mouse Brain Monoamine Oxidase (MAO) in vitro
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Yoo, Ick Dong
LEE, SANG JUN/LEE, IN KYOUNG/Oh, Seung Uk/Chung, Ha Yull
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Abstract
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Thirty-seven naturally occurring flavonoids were investigated for their inhibitory activities on the mouse brain monoamine oxidase (MAO). Three flavonoids, apigenin (IC_50; 1 μmol), liquiritigenin (IC_(50); 4 μ㏖) and genistein (5 μ㏖), were judged to be very active, four flavonoids, quercetin, leuteolin and eupatilin were moderately active with IC_(50) values of 10-20 μ㏖. 6-Methoxy flavonoids showed considerable activities with IC_(50) values of 20 μ㏖-40 μ㏖, while most isoflavones except genistein and daidzein showed weak activities. According to the results of structure-activity relationship of flavonoids as inhibitors of MAO, three hydroxyl groups at C-5 and C-7 on A ring and C-4´ on B ring of flavone/flavanone seems to be essential for the inhibitory activity, and ortho catechol moiety at B ring showed somewhat weaker activity. Flavone/flavanone glycosides showed weaker inhibitory activity than their corresponding flavone/flavanone, and double bonds between C-2 and C-3 were not critical for the inhibitory activity on MAO enzyme. As for polymethoxylated flavones, 6-methoxyl group was assumed to be important for the moderate inhibitory activity.
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